High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions

Rapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid

UNLABELLED Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but have required 2.5 to 5 days. Here, an improved RT-QuIC assay is described whic...

Diagnostic performance of CSF biomarkers in CJD

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.

OBJECTIVE Several prion amplification systems have been proposed for detection of prions in cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with second-generation real-time quaking-induced conversion (RT-QuIC). The objective of this study was to investigate the diagnostic performance of the RT-QuIC prion test in the broad phenotypic spectrum of prion disease...

the impact of training on second language writing assessment: a case of raters’ biasedness

چکیده هدف اول این تحقیق بررسی تأثیر آموزش مصحح بر آموزش گیرندگان براساس پایایی نمره های آنها در پنج بخش شامل محتوا ، سازمان ، لغت ، زبان و مکانیک بود. هدف دوم این بود که بدانیم آیا تفاوتهای بین آموزشی گیرندگان زن و مرد در پایایی نمرات آنها وجود دارد. برای بررسی این موارد ، ما 90 دانشجو در سطح میانه (متوسط) که از طریق تست تعیین سطح شده بودند انتخاب شدند. بعد از آنها خواستیم که درباره دو موضوع ا...

BRIEF COMMUNICATION Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies Graham Fairfoul, Lynne I. McGuire, Suvankar Pal, James W. Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G. Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T. M. Hu, Laura Parkkinen & Alison J. E. Green The National CJD Research & Surveillance Un...